ParkinsonCanadaV1, Main, Exploration, bibRecord, 000A23

Investing in the Future: Stimulation of the Medial Prefrontal Cortex Reduces Discounting of Delayed Rewards

Identifieur interne : 000A23 ( Main/Exploration ); précédent : 000A22; suivant : 000A24

Investing in the Future: Stimulation of the Medial Prefrontal Cortex Reduces Discounting of Delayed Rewards

Auteurs : Sang Soo Cho [Canada] ; Yuko Koshimori [Canada] ; Kelly Aminian [Canada] ; Ignacio Obeso [Canada] ; Pablo Rusjan [Canada] ; Anthony E. Lang [Canada] ; Zafiris J. Daskalakis [Canada] ; Sylvain Houle [Canada] ; Antonio P. Strafella [Canada]

Source :

Neuropsychopharmacology [ 0893-133X ] ; 2014.

RBID : PMC:4289950

English descriptors

KwdEn :
- Carbon Radioisotopes (metabolism), Corpus Striatum (metabolism), Delay Discounting (physiology), Dopamine (metabolism), Female, Functional Neuroimaging, Humans, Male, Oxazines (metabolism), Positron-Emission Tomography, Prefrontal Cortex (metabolism), Prefrontal Cortex (physiology), Reward, Transcranial Magnetic Stimulation, Young Adult.
MESH :
- chemical , metabolism : Carbon Radioisotopes, Dopamine, Oxazines.
- metabolism : Corpus Striatum, Prefrontal Cortex.
- physiology : Delay Discounting, Prefrontal Cortex.
- Female, Functional Neuroimaging, Humans, Male, Positron-Emission Tomography, Reward, Transcranial Magnetic Stimulation, Young Adult.

Abstract

Generally, rewards that are received sooner are often preferred over future rewards, and the time between the choice and the reception of the reward is an important factor that influences our decisions, a phenomenon called delay discounting (DD). In DD, the medial prefrontal cortex (MePFC) and striatal dopamine neurotransmission both play an important role. We used repetitive transcranial magnetic stimulation (rTMS) to transiently activate the MePFC to evaluate its behavioral effect on the DD paradigm, and subsequently to measure its effect on striatal dopamine. Twenty-four right-handed young healthy subjects (11 females; age: 22.1±2.9 years) underwent DD following 10 Hz-rTMS of the MePFC and vertex stimulation (control condition). Thereafter, 11 subjects (5 females; age: 22.2±2.87 years) completed the PET study at rest using [¹¹C]-(+)-PHNO following 10 Hz-rTMS of the MePFC and vertex. Modulation of the MePFC excitability influenced the subjective level of DD for delayed rewards and interfered with synaptic dopamine level in the striatum. The present study yielded findings that might reconcile the role of these areas in inter-temporal decision making and dopamine modulation, suggesting that the subjective sense of time and value of reward are critically controlled by these important regions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289950

DOI: 10.1038/npp.2014.211
PubMed: 25168685
PubMed Central: 4289950

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Generally, rewards that are received sooner are often preferred over future rewards, and the time between the choice and the reception of the reward is an important factor that influences our decisions, a phenomenon called delay discounting (DD). In DD, the medial prefrontal cortex (MePFC) and striatal dopamine neurotransmission both play an important role. We used repetitive transcranial magnetic stimulation (rTMS) to transiently activate the MePFC to evaluate its behavioral effect on the DD paradigm, and subsequently to measure its effect on striatal dopamine. Twenty-four right-handed young healthy subjects (11 females; age: 22.1±2.9 years) underwent DD following 10 Hz-rTMS of the MePFC and vertex stimulation (control condition). Thereafter, 11 subjects (5 females; age: 22.2±2.87 years) completed the PET study at rest using [<sup>11</sup>
C]-(+)-PHNO following 10 Hz-rTMS of the MePFC and vertex. Modulation of the MePFC excitability influenced the subjective level of DD for delayed rewards and interfered with synaptic dopamine level in the striatum. The present study yielded findings that might reconcile the role of these areas in inter-temporal decision making and dopamine modulation, suggesting that the subjective sense of time and value of reward are critically controlled by these important regions.</p>
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       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Investing in the Future: Stimulation of the Medial Prefrontal Cortex Reduces Discounting of Delayed Rewards

Investing in the Future: Stimulation of the Medial Prefrontal Cortex Reduces Discounting of Delayed Rewards

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.